Increased Uncoupling of .BETA.-,.BETA.1-and .BETA.2-Adenoceptor to Myocardial Contraction in Failing Human Myocardium.
نویسندگان
چکیده
منابع مشابه
Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium.
BACKGROUND Contrary to beta(1)- and beta(2)-adrenoceptors, beta(3)-adrenoceptors mediate a negative inotropic effect in human ventricular muscle. To assess their functional role in heart failure, our purpose was to compare the expression and contractile effect of beta(3)-adrenoceptors in nonfailing and failing human hearts. METHODS AND RESULTS We analyzed left ventricular samples from 29 fail...
متن کاملThe α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium.
Dysfunction of the right ventricle (RV) is closely related to prognosis for patients with RV failure. Therefore, strategies to improve failing RV function are significant. In a mouse RV failure model, we previously reported that α1-adrenergic receptor (α1-AR) inotropic responses are increased. The present study determined the roles of both predominant cardiac α1-AR subtypes (α1A and α1B) in upr...
متن کاملIncreased de novo ceramide synthesis and accumulation in failing myocardium.
Abnormal lipid metabolism may contribute to myocardial injury and remodeling. To determine whether accumulation of very long-chain ceramides occurs in human failing myocardium, we analyzed myocardial tissue and serum from patients with severe heart failure (HF) undergoing placement of left ventricular assist devices and controls. Lipidomic analysis revealed increased total and very long-chain c...
متن کاملReduced Stretch-Induced Force Response in Failing Human Myocardium Caused by Impaired Na -Contraction Coupling
Background—Stretch elicits an immediate, followed by a delayed, inotropic response in various animal models and failing human myocardium. This study aimed to characterize functional differences in the stretch response between failing and nonfailing human myocardium. Methods and Results—Experiments were performed in muscle tissue from 86 failing and 16 nonfailing human hearts. Muscles were stret...
متن کاملReduced stretch-induced force response in failing human myocardium caused by impaired Na(+)-contraction coupling.
BACKGROUND Stretch elicits an immediate, followed by a delayed, inotropic response in various animal models and failing human myocardium. This study aimed to characterize functional differences in the stretch response between failing and nonfailing human myocardium. METHODS AND RESULTS Experiments were performed in muscle tissue from 86 failing and 16 nonfailing human hearts. Muscles were str...
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ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1992
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.56.701